To decide between Greedy and Dynamic Programming (DP), first check if the problem has optimal substructure, meaning the problem can be broken into smaller subproblems whose optimal solutions combine to solve the bigger problem. If this is false, neither approach works well. Next, check if the problem has overlapping subproblems, meaning the same subproblems appear multiple times. If yes, DP is preferred because it stores results to avoid repeated work. If no overlapping subproblems, greedy approach is better as it makes local optimal choices without extra storage. This decision flow helps pick the right method for efficient problem solving.