The IS DISTINCT FROM operator in PostgreSQL compares two values and returns TRUE if they are different, including when one is NULL and the other is not. It returns FALSE if the values are equal or both are NULL. This operator is NULL-safe, meaning it treats two NULLs as equal, unlike the standard <> operator which returns NULL when comparing with NULLs. The execution flow first checks if both values are NULL, then if they are equal, and finally returns TRUE if neither condition is met. This makes IS DISTINCT FROM very useful for comparisons where NULLs might appear and you want a clear TRUE or FALSE result.