In Node.js, when handling HTTP requests, you use response methods to send data back to the client. First, you can set the status code with res.status(code). This changes the HTTP status like 404 for Not Found or 200 for OK. Then, you send the response body with res.send(body). These methods can be chained so that res.status(404).send('Not Found') sets the status and sends the message in one go. If you don't set a status, it defaults to 200. The client receives both the status code and the response body together. This flow ensures clear communication about the result of the request.