When a client sends a POST request, the server first checks the Content-Type header to decide how to parse the body. If the Content-Type is application/json, the express.json() middleware parses the JSON string into a JavaScript object and stores it in req.body. If the Content-Type is application/x-www-form-urlencoded, the express.urlencoded() middleware parses the form data string into an object with string values and stores it in req.body. If the Content-Type is unsupported, no parser runs and req.body remains empty. The route handler then uses req.body to access the parsed data and sends it back as a JSON response. This process ensures the server understands the client's data format and can work with it easily.