Block scope in JavaScript means variables declared with let or const only exist inside the curly braces { } where they are declared. In the example, x is declared inside an if block with let. Inside the block, x has the value 5 and can be used. But outside the block, x does not exist, so trying to use it causes a ReferenceError. This shows how block scope protects variables from being accessed outside their intended area. Variables declared with var do not have block scope and can be accessed outside blocks, which can cause bugs. Using let and const helps keep variables contained and safer.