Schema validation in Express means checking incoming request data against a set of rules called a schema. When the server gets a request, it extracts the data and compares it to the schema. If the data matches the rules, the server continues processing. If not, it sends back an error message and stops. For example, if the schema says 'name' must be a string, and the request sends a number instead, the server will respond with a 400 error. This process helps keep the app safe and working correctly by catching bad data early.