Express is a framework for Node.js that helps create web servers easily. First, you import Express and create an app instance by calling express(). Then, you define routes like app.get('/') to tell the app how to respond to requests. After defining routes, you start the server with app.listen(3000), which listens for incoming HTTP requests on port 3000. When a request matches a route, Express runs the route handler function, which sends a response back to the client. The server keeps running, ready to handle more requests. This flow makes building web servers simple and organized.