In Express, you can create a router and attach it to your main app at a specific path prefix. When a request comes in, Express checks if the URL starts with that prefix. If it does, the router handles the request using its defined routes. For example, mounting a router at '/prefix' means requests to '/prefix' or '/prefix/' trigger the router's handlers. Requests to '/prefix/extra' or other paths do not match the router's root route and so are not handled by it. This lets you group routes logically under a common path segment, making your app easier to manage.