In Express, when a request comes in, the route handler runs. If an error happens, instead of sending a response immediately, the route calls next(error). This passes the error to a special middleware called the centralized error handler, which has four parameters: err, req, res, next. This middleware sends a response with the error message and status code. If no error occurs, the route sends the normal response. This keeps error handling in one place and makes code cleaner. The error handler middleware must be added after all routes. The execution table shows the steps: request received, error detected, next(error) called, error handler runs, response sent. Variables like req.query.id, error, res.statusCode, and res.body change accordingly during these steps.