In WordPress, permission callbacks are functions that check if a user has the right to access a REST API route. When a request comes in, WordPress calls the permission callback first. This callback checks user capabilities or other conditions and returns true or false. If it returns true, WordPress runs the main callback to provide data or perform actions. If it returns false, WordPress denies access and does not run the main callback. This ensures security by preventing unauthorized users from accessing sensitive routes. The example code shows a permission callback checking if the user can edit posts. The execution table traces requests where the callback returns true or false and shows the resulting access. The variable tracker shows how the permission callback result affects access granted. Key moments clarify why the permission callback runs first and what happens when it returns false. The quiz tests understanding of these steps. Remember, always use permission callbacks to protect your REST API routes in WordPress.