Data sanitization in WordPress means cleaning user input before using it. The process starts when user input is received, then a sanitization function like sanitize_text_field is applied to remove harmful code such as HTML tags or scripts. The cleaned data is then safe to display or store in the database. This prevents security issues like cross-site scripting. For example, if a user inputs a script tag, sanitize_text_field removes the tags and leaves only the text. Different data types need different sanitizers, such as esc_url_raw for URLs. Always sanitize data to keep your WordPress site secure.