In Spring Boot, you can create custom queries by simply naming methods in your repository interface. For example, a method named findByLastName will be parsed by Spring Data to generate a query that selects users where the last_name matches the given parameter. When you call this method with a value like 'Smith', Spring runs the query and returns the matching users. This process involves Spring reading the method name, converting it into a SQL query, executing it, and returning the results. If the method name does not follow the naming rules, Spring will not be able to generate the query and will throw an error. This feature lets you write queries without writing SQL, just by naming methods clearly.