When Redis server starts, it loads a configuration file that sets important settings like memory limits and eviction policies. These settings control how Redis behaves when handling data. For example, setting maxmemory limits how much data Redis can store. When this limit is reached, the eviction policy decides which keys to remove to free space. Without configuration, Redis uses default settings which may not limit memory or evict keys, potentially causing problems. Changing configuration changes how Redis stores and removes data, affecting client requests and server performance.