Using relative and absolute positioning affects how React Native calculates layout. Relative positioning shifts elements without removing them from the layout flow, so it has minimal impact on performance. Absolute positioning removes elements from the normal flow, which can increase layout calculation time if overused, especially in complex screens.
Excessive use of absolute positioning can cause frame drops below 60fps because the system recalculates positions on every frame during animations or screen changes. Memory impact is low unless many positioned elements are layered with transparency.