CORS configuration controls which websites can access your server's resources. When a client sends a request, the server checks the Origin header. If the origin matches allowed sites, the server adds CORS headers to the response. This tells the browser it's safe to share data. If the origin is not allowed, the server does not add these headers, so the browser blocks the response. In Node.js with Express, the cors middleware simplifies this by letting you specify allowed origins. This example allows only https://example.com. Requests from other origins get no CORS headers and are blocked by browsers. Requests without an Origin header, like same-origin requests, get no CORS headers but are allowed by browsers since they are same-origin.