In Node.js, the global object is called global. In browsers, it's window. Objects like document and navigator are browser-specific.
The 'fs' module is part of Node.js for file system operations. Browsers do not have access to this module, so trying to use it causes a ReferenceError.
Node.js supports ES Modules natively but requires either the .mjs file extension or setting 'type':'module' in package.json. Browsers support ES Modules natively without needing special extensions.
Node.js event loop has multiple phases including timers and I/O callbacks, which affects when timers run. Browsers have a simpler event loop model.
Node.js does not have a 'document' object because it does not run in a browser environment. Trying to access 'document' causes a ReferenceError.