In NestJS, third-party middleware such as helmet and cors are imported and applied globally using app.use(). When the app starts, these middleware are ready to process incoming requests. Each request passes through helmet first, which adds security headers to the response, then through cors, which adds headers to allow cross-origin requests. After middleware processing, the request reaches the route handler, which sends the response back to the client with the added headers. The variable tracker shows that the request object remains unchanged by these middleware, while the response headers accumulate security and CORS information. This flow ensures all responses are secure and accessible from other origins. Middleware order is important because it determines the sequence of processing. Removing cors middleware would mean no CORS headers are added, potentially blocking cross-origin requests.