In NestJS, pipes can be bound at four levels: global, controller, method, and parameter. When a request arrives, it first passes through global pipes that apply to all routes. Then controller-level pipes run, affecting all methods in that controller. Next, method-level pipes run if defined, and finally, parameter-level pipes run on specific parameters. This layered approach allows precise control over data validation and transformation. For example, a global ValidationPipe can check the whole request structure, while a ParseIntPipe on a parameter converts a string to a number before the controller method uses it. This flow ensures data is clean and correctly typed before business logic runs.