Serializers in Django REST Framework help convert Python objects like dictionaries into JSON data and convert JSON data back into Python objects after validation. The process starts by creating a serializer instance with Python data, then accessing serializer.data to get a JSON-like dictionary. When receiving JSON input, you create a serializer with that data and call is_valid() to check if the data meets the serializer's rules. If valid, you access validated_data to get Python objects. If invalid, serializer.errors contains messages explaining what went wrong. This flow ensures data is safely converted and validated between Python and JSON formats.