Clickjacking protection in Django works by adding a special HTTP header called X-Frame-Options to responses. This header tells the browser whether the page can be shown inside a frame or iframe. Django provides middleware called XFrameOptionsMiddleware that automatically adds this header to all responses. You can also use decorators like @xframe_options_deny on views to set this header per view. When the browser sees the header set to DENY or SAMEORIGIN, it blocks the page from being framed by other sites. This stops attackers from tricking users into clicking hidden buttons or links, protecting against clickjacking attacks. The execution flow starts with the user request, then Django processes it, the middleware adds the header, and finally the browser enforces the protection when rendering the page.