Cache invalidation in Django means removing or updating cached data when the original data changes. This prevents users from seeing old information. The process starts when data in the database changes. Django then finds which cached data is affected. It either deletes that cache entry or updates it with new data. For example, after updating a user's profile, the cache key 'user_profile_42' is deleted. The next time the profile is requested, fresh data is fetched from the database and stored in the cache. This way, the cache always serves up-to-date information. Without invalidation, the cache would keep serving old data, confusing users. So, always remember to invalidate cache after data changes.